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Two of those—interleukin-1α and CXCL8—remained statistically significant even after accounting for potential confounding factors.

Tansey says there are other factors supporting the gut-brain connection.

“Maybe different strains, different conformations of alpha synuclein will lead to different diseases,” he said.

People with multiple system atrophy or MSA mimic many of the symptoms of people with PD—progressive gait imbalance, slurred speech and some cognitive impairment—so it’s not unusual for clinicians to misdiagnose.There was also a panel discussion centered on the role of the gut microbiome in brain function and neuroinflammation, and a heartbreaking talk about a rare disease, called Multiple System Atrophy (MSA), that appears to be linked to neuroinflammation.(Proceeds from Charles River symposium were donated to the Multiple System Atrophy Coalition, which assists researchers in finding a cure and provides support to patients and caregivers.) If there was a common thread among all of these talks it was that better drugs are needed for diseases of the central nervous system, and that inflammatory processes in the brain and spinal cord, prominent in many of CNS conditions, are a good place to look.the genetic regulation of neural mechanisms, and their modulation by environmental circumstances, that impact upon cognitive function, cognitive reserve and flexibility, learning, and memory; 8) Studies to investigate gene by environmental covariation.

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